The key to the effectiveness of Estrogen Balance® is it's unique combination of D.I.M. , Quercetin and Flax Seed together, which work synergistically and with greatly increased overall bioavailbility. That is why Nature's Health Supply has uniquely formulated them together in Estrogen Balance®

Many researchers including John R. Lee, M.D, Dr. Jesse Hanley and Dr. Peter Eckhart have concluded that an over abundance of estrogen is responsible for a vast number of today's health problems. This over abundance of estrogen is referred to as "estrogen dominance" and is an increasingly serious problem for both women and men. Dr. Lee believes that "estrogen dominance" is the primary cause of prostate enlargement and prostate cancer in men and a big risk factor for breast cancer in women.

"Estrogen dominance" can occur as we age and can also occur from exposure to "estrogen like" substances in the environment known as "xenoestrogens".

Xenoestrogens are synthetic substances that differ from those produced by living organisms and imitate or enhance the effect of estrogens. The estrogenic stimulation is an unintended side-effect of these agents or their metabolites. Xenoestrogens are part of a heterogeneous group of chemicals that are hormone or endocrine disruptors. They differ from phytoestrogens (estrogenic substances from plants), mycoestrogens (estrogenic substances from fungi), and pharmacological estrogens (estrogenic action is intended). External estrogens from a variety of sources may have a cumulative effect upon living organisms, and xenoestrogens may be part of a larger picture of a process of estrogenization of the environment. Xenoestrogens have only been recently (less than 70 years) introduced into the environment, as produced by industrial, agricultural, and chemical companies.

Xenoestrogens have been implicated in a variety of medical problems. Foremost is the concern that xenoestrogens as false messengers disrupt the process of reproduction. Studies have implicated observations of disturbances in wildlife with estrogenic exposure. Reproductive issues which are of concerns in humans are fetal exposure (perhaps leading to hypospadia) and decreased reproductive ability in men (i.e. decrease in sperm numbers). Another issue is the potential effect of xenoestrogens as oncogenes, specifically in relation to breast cancer.

Many people don't know this, but men and women actually have the exact same hormones, just in different amounts. So both men and women have estrogen. Actually there is no "estrogen" per se . . . "estrogen" is just a convenient term which refers to the whole class of hormones collectively known as estrogens. There are actually three basic estrogens:

1. E3 (estriol) - the least powerful and most beneficial, comprises 80-90% of human estrogen
2. E2 (estradiol) - the most powerful and most carcinogenic
3. E1 (estrone) - has similar properties to estradiol but is considerably less biologically active

With anti-estrogens in the diet, such as those contained in Estrogen Balance®, estrogen metabolism is aerobic. This very efficient metabolism results in the predominance of 2-hydroxy and 2-methoxyestrogens. These "good estrogen" metabolites function as antioxidants, and have the power to eliminate damaged or cancerous cells throughout the body.

Without anti-estrogens in the diet, such as those contained in Estrogen Balance®, estrogen metabolism is anaerobic. This very inefficient metabolism results in a predominance of 16-hydroxy estrone and 4-hydroxy estrone. These "bad estrogen" metabolites act negatively to allow oxidation, to damage DNA, and to promote cancer.

Men also produce progesterone, but only about half the amount that females do. During the aging process, progesterone levels in men fall, especially after age 60. Progesterone is the primary precursor of the male hormone testosterone, which is an antagonist to estradiol (E2) and a protector against certain types of cancer. Progesterone is vital to good health in both women and men.

The concurrent increase of estrogen levels and decrease of progesterone levels creates a very serious hormonal imbalance which is very unhealthy. Either one of these hormonal level changes would be bad enough, but both changes occurring together leads to a vicious cycle:

Because progesterone is the chief inhibitor of an enzyme called 5-alpha reductase that is responsible for converting testosterone to dihydrotestosterone (DHT), when the level of progesterone falls in men, the amount of conversion from testosterone to DHT increases. Increased levels of DHT lead to prostate enlargement and also an increased risk of cancer due to the decrease cancer protection that testosterone provides.

As the level of DHT increases (and testosterone decreases), the relative level of estradiol in men increases. Estradiol, turns on BCL2 oncogene (onco means cancer) and increases the risk of prostate cancer. This is compounded by the fact that there are inadequate amounts of progesterone there to exhibit it's counteracting effect of stimulating the P53 cancer protection gene.

Like perimenopausal women, men experience a tendency to gain weight in midlife. Rising estrogen production can result, since fat cells contain the aromatase enzyme that converts testosterone into estrogen. Unmetabolized estrogen creates a vicious cycle resulting in further estrogen production. This occurs because fat is one source of more active aromatase enzymes, causing further estrogen production and continuing weight gain.

Estrogen dominance can start early on in a women's menstrual cycle. Young women who suffer from this enter menarche with tremendously difficult periods, and doctors sometimes give these teenage girls birth control pills to help regulate the frequency and severity of their periods.

Some women will develop the estrogen dominance syndrome much later in life, sometimes as a result of diet, liver impairment, or environmental factors or also as a result of anovulatory cycles before menopause -- that is, menstrual cycles in which no ovulation has occurred. Ovulation is necessary in order to produce the corpus luteum, (which means "yellow body") that is found on the surface of the ovary after ovulation. Surrounding the ripening egg, the corpus luteum remains after ovulation to produce progesterone for the last half of the menstrual cycle. Without ovulation, less progesterone is produced, which can cause estrogen imbalance in some women.

Diseases or problems that are thought to be related to or effected by excess estrogen and deficient progesterone in women are:

• Speeds up the aging process • Allergies • Autoimmune disorders • Breast cancer • Breast tenderness • Cold hands and feet • Decreased sex drive • Depression • Dry eyes • Infertility • Uterine cancer • Fat gain in abdomen, hips, and thighs • Fatigue • Fibrocystic breasts disease • Hair loss • Headaches

• Hypoglycemia • Increased blood clotting • Early onset of menstruation • Menstrual disturbances (irregular and heavy bleeding) • Endometriosis (disorder of uterine tissue) • Insomnia • Foggy thinking and Memory loss • Mood swings • Ovarian cysts • Pre-menopausal bone loss • Prostate cancer • Sluggish metabolism • Thyroid dysfunction • Uterine cancer • Uterine fibroids • Water retention and bloating

Those of us who are "into" natural medicine have turned to the logical alternative: Natural Hormone Replacement (NHR), using hormones identical in every way to the ones our own bodies produce, in quantities to which our bodies are accustomed, on schedules for which our bodies are already "programmed". In this way, we hope to minimize our risk of cancer from hormone ingestion while maximizing our chances of preventing heart and blood vessel disease, osteoporosis, and cognitive decline.

Of course, sex-hormone-related cancer has been on a decades-long uptrend, including those who have never had any hormone replacement. Young women as well as old are developing more breast cancers than ever before, and the rate of prostate cancer is climbing among men, most of whom have never taken testosterone.

D.I.M. is formed from its precursor indole, Indole-3-carbinol (I3C), after the enzymatic release of I3C from parent glucosinolates found in all cruciferous vegetables. It is twice as strong as 13C and has been shown in studies to be helpful for both men and women, providing the following health benefits:

1. promotes healthy estrogen metabolism
2. promotes fat loss
3. protects against heart disease
4. protects against cancer
5. promotes health skin and bones
6. promotes health brain tissue
7. in men it supports healthy prostate tissues
8. in women it supports healthy breast, cervical and uterine tissues
9. in women it relieves PMS symptoms

When D.I.M. increases the "good" estrogen metabolites, there is a simultaneous reduction in the levels of "bad" estrogen metabolites, which unlike the good" metabolites are NOT antioxidants and are actually quite harmful.

These "bad" estrogen metabolites are responsible for many of estrogen's undesirable actions in women and men, including further unwanted weight gain, breast cancer, uterine cancer, and prostate cancer.

In Women, D.I.M. helps to restore estrogen balance during perimenopause. Studies have shown that D.I.M. is beneficial for women dealing with: breast cancer, ovarian cancer, uterine cancer, uterine fibroid tumors, fribrocystic breasts, cervical dysplasia, and SLE (systemic lupus erythematosis). D.I.M. is highly recommended for women on HRT (hormone replacement therapy) or at risk for breast cancer as it will reduce the toxic effects to estrogen dominance.

In Men D.I.M. helps to eliminate active estrogen by promoting its conversion into the "good" metabolites. These metabolites then free up testosterone by bumping it off the testosterone-binding proteins. The end result is a healthier balance of testosterone to estrogen and more free (unbound) testosterone circulating in the body. This has been linked to lean body mass, an efficient fat-burning metabolism, low abdominal obesity, increased libido, lower incidence of prostate enlargement (BPH) and a dramatically lower risk of prostate cancer.

D.I.M. has been shown in overweight men and women to promote more efficient weight loss and more active fat metabolism.

Another recent published study demonstrates quercitin provides long-term symptomatic relief with few side effects to men that are afflicted with nonbacterial prostatitis.

More than 80% of chronic prostatitis patients who took a proprietary formulation of quercetin, a natural dietary supplement, significantly reduced pain and improved their quality of life, according to a new study published in the December issue of Urology. This marks the first time any tested therapy for chronic prostatitis has produced such demonstrative results.

The randomized, double-blind, placebo-controlled study, conducted by researchers at the Institute for Male Urology in Encino, Calif, found that 82% of patients who received quercetin, recorded at least a 25% improvement in the National Institutes of Health pain and quality of life symptom score.

"These impressive findings should offer hope to the millions of men who suffer from this poorly understood and painful condition, as it provides a new option for doctors who've been frustrated by limited treatment choices," said lead researcher Daniel A. Shoskes, MD, a renal transplant specialist and associate professor of urology at the University of California Los Angeles School of Medicine. "Importantly, all of these men had failed multiple courses of antibiotics and other therapies before participating in this study."

Nonbacterial chronic prostatitis is an inflammation of the prostate gland that effects an estimated 30 million men in the United States. Its chief symptom is chronic urogenital pain, and it is believed to impact quality of life as dramatically as myocardial infarction and Crohn disease. Its etiology is poorly understood, and standard antibiotic treatments have offered limited success.

Dr. Shoskes, who had successfully used quercetin in preclinical studies with kidney transplants, decided to test the therapy on prostatitis patients, since an inflammatory cause is strongly suspected. Results with the formulation were so convincing, the researchers concluded the study early. "Chronic prostatitis is an enormous problem in our country and around the world," Dr. Shoskes said. "It's one of the most common reasons why men visit urologists, and it's one of the most discouraging conditions doctors face, because often times there's very little we can do to alleviate the pain."

Quercetin acts as an antihistamine and has anti-inflammatory properties. As an antioxidant, it protects LDL cholesterol ("bad" cholesterol) from becoming damaged. A variety of evidence indicates that quercetin possesses potent anti-oxidant properties. Cardiologists believe that damage to LDL cholesterol is an underlying cause of heart disease. Quercetin blocks an enzyme that leads to accumulation of sorbitol, which has been linked to nerve, eye, and kidney damage in those with diabetes.

Quercetin has been used in connection with the following conditions:

1. Prostatitis (nonbacterial prostatitis, prostadynia)
2. Allergies
3. Asthma
4. Atherosclerosis
5. Capillary fragility
6. Cataracts
7. Childhood diseases
8. Diabetes
9. Edema (water retention)
10. Gout
11. Hay fever
12. Peptic ulcer
13. Retinopathy

One of the best sources of omega-3 is Flaxseed. Flax is an ancient crop, native to Eurasia. Its first recorded use comes from Babylon -- about 3000 B.C. There, it was cultivated for food. It also was used to make a fabric used in clothing. (These days, linen comes from flax). Hippocrates, the ancient Greek physician called the "father of medicine," wrote of using flaxseed for the relief of abdominal pain. And, the greatest of all medieval kings, Charlemagne, considered flax so healthy that he passed laws requiring its consumption.

Nutrition researchers have identified several substances in flaxseed that appear to have health benefits: lignans, fiber, and omega-3 fatty acids:

Lignans are phytoestrogens (phyto = plant) that are thought to bind to estrogen receptors in the body and may have a role in preventing hormonally related cancers of the breast, endometrium and prostate. Populations with higher intakes of phytoestrogens seem to have a lower incidence and mortality from these cancers. The American Institute for Cancer Research has funded a study testing the effects on lignans and breast tumor development in humans. Although lignans are found in most unrefined grains (barley, buckwheat, millet and oats), soybeans, and some vegetables (broccoli, carrots, cauliflower and spinach), flaxseed is the richest source.

Flaxseed contains both soluble and insoluble fiber (about 28 grams total fiber per 100 grams of flaxseed). About one-third of the fiber is soluble. Studies have found that the soluble fiber in flaxseed -- like that found in oat bran and fruit pectin -- can help lower cholesterol. Soluble fiber also has been found to help regulate blood sugar levels.

The remaining two-thirds of the fiber in flaxseed is insoluble. Insoluble fiber aids digestion by increasing bulk, reducing the time that waste remains in the body and preventing constipation. These characteristics seem to have a role in protecting against cancer.

Flaxseed also is rich in alpha-linolenic acid that is both an essential fatty acid and an omega-3 fatty acid. Researchers are interested in omega-3 fatty acids for their roles in proper infant growth and development, reducing risk factors for heart disease and stroke (regulation of cholesterol, triglycerides, blood pressure, blood clotting), immune and inflammatory disorders.

Flaxseed lignans are very powerful antioxidants and also act as anti-estrogens, offering significant potential for both men and women's health. Lignans are currently being researched for their role in diseases including Benign Prostatic Hyperplasia (BPH) or enlargement of the prostate gland, and prostate cancer. They could also be used in products to help prevent hair loss, as trials have found lignans to benefit both men and women with androgenetic alopecia.

Prostate Miracle® Prostate Miracle® is a great Companion product to Estrogen Balance™ 95% effective in     decreasing enlarged prostate Reduces risk of Prostate Cancer Contains: Beta Sitosterol (300 mg/caplet) Zinc Citrate (7.5 mg/caplet) Selenium (100 mcg/caplet) Vitamin D3 (1000 iu's/caplet) Suggested use: 1 caplet twice per day 60 caplets per bottle     (30 day supply) Click Here for more Info 1 bottle - $25.95 2 bottles - $21.95 each $43.90 3 bottles - $18.95 each $56.95 6 bottles - $15.95 each $95.70

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